[2] He et al. (2018). Ephrin/Eph signaling in development and disease. Journal of Developmental Biology, 66, 53-64.
The Eph family of receptor tyrosine kinases (RTKs) is the largest family of RTKs, comprising 14 members in mammals (EphA1-10 and EphB1-4) [1]. These receptors are activated by their ligands, a group of membrane-bound proteins known as ephrins, which are divided into two classes: EphrinA (eA) and EphrinB (eB) [2]. The interaction between Eph receptors and ephrins triggers a cascade of downstream signaling events that ultimately regulate various cellular responses. ephti biochemistry pdf
[4] Zhang et al. (2015). Src family kinases in Eph/Ephrin signaling. Journal of Cell Science, 128(10), 1823-1832. [2] He et al
[3] Li et al. (2017). Molecular mechanisms of Eph/Ephrin signaling. Journal of Biological Chemistry, 292(15), 6223-6232. Journal of Developmental Biology, 66, 53-64
[5] Wang et al. (2015). Rho GTPases in Eph/Ephrin-mediated cell migration. Journal of Cell Biology, 210(3), 465-478.
The Eph family of receptor tyrosine kinases and their ephrin ligands have emerged as crucial regulators of various cellular processes, including cell migration, patterning, and differentiation. The intricate interactions between Eph receptors and ephrins play a vital role in the development and maintenance of tissue architecture, as well as in disease progression. This article aims to provide an in-depth overview of the Eph/Ephrin signaling pathway, its biochemical mechanisms, and its implications in various physiological and pathological processes.